Pr. Hervé Kovacic
First Name / Last Name : Hervé Kovacic
Title or function : Professor in Biomathematics and Biophysic (PhD).
Affiliation (Lab, university, company) : Institut de Neurophysiopathologie, UMR CNRS 7051, INP
First Name / Last Name : Hervé Kovacic
Title or function : Professor in Biomathematics and Biophysic (PhD).
Affiliation (Lab, university, company) : Institut de Neurophysiopathologie, UMR CNRS 7051, INP
Professor at Aix Marseille University since 2007, in the Department of Biophysics and Biomathematics, of the Faculty of Pharmacy of Marseille.
Team leader in INSERM and CNRS lab’s since 2011 working mostly on the involvement of cytoskeleton and oxidative stress in cancer.
Deputy Director since 2018 of the “Institut of Neurophysiopathologie” UMR 7051, in charge of facilities development (Imaging, Stem cells, Interactoma including Mass spec, SPR and Microcalorimetry).
Pagano A, Breuzard G, Parat F, Tchoghandjian A, Figarella-Branger D, De Bessa TC, Garrouste F, Douence A, Barbier P, Kovacic H. Tau Regulates Glioblastoma Progression, 3D Cell Organization, Growth and Migration via the PI3K-AKT Axis. Cancers (Basel). 2021 Nov 19;13(22):5818. doi: 10.3390/cancers13225818. PMID: 34830972..
Annweiler C, Cao Z, Wu Y, Faucon E, Mouhat S, Kovacic H, Sabatier JM. Counter-regulatory 'Renin-Angiotensin' System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected Patients. Infect Disord Drug Targets. 2020;20(4):407-408. doi: 10.2174/1871526520666200518073329. PMID: 32418532.
De Bessa TC, Pagano A, Moretti AIS, Oliveira PVS, Mendonça SA, Kovacic H, Laurindo FRM. Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas. Cell Death Dis. 2019 Feb 13;10(2):143. doi: 10.1038/s41419-019-1402-y. PMID: 30760703.
Sadok A, Bourgarel-Rey V, Gattacceca F, Penel C, Lehmann M, Kovacic H. Nox1-dependent superoxide production controls colon adenocarcinoma cell migration. Biochim Biophys Acta. 2008 Jan;1783(1):23-33. doi: 10.1016/j.bbamcr.2007.10.010. Epub 2007 Oct 30. PMID: 18023288 .
Dahan L, Sadok A, Formento JL, Seitz JF, Kovacic H. Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines. Br J Pharmacol. 2009 Sep;158(2):610-20. doi: 10.1111/j.1476-5381.2009.00341.x. PMID: 19732064 Free PMC article..
Kovacic HN, Irani K, Goldschmidt-Clermont PJ. Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells. J Biol Chem. 2001 Dec 7;276(49):45856-61. doi: 10.1074/jbc.M107925200. Epub 2001 Oct 3. PMID: 11585836.